DES: Exposure Risk and Consequences
Attention: If you were born between
1938 and 1971, or if you were pregnant during this time the information
that follows could have a profound impact on your health.
Did your mother take "vitamins" during her pregnancy? Of course,
all women should take good prenatal vitamins during pregnancy. But
many women who were pregnant between 1938 and 1971 took vitamins
that were not vitamins at all. Physicians often told women they
were taking vitamins when what they were really taking was diethystilbestrol,
more commonly referred to as DES.
DES is a synthetic estrogen that was given to millions of pregnant
women during these years because the medical profession believed
it would help prevent miscarriage and insure a healthy full term
pregnancy. A 1957 advertisement claimed desPLEX® would "prevent
ABORTION, MISCARRIAGE and PREMATURE LABOR…recommended for routine
prophylaxis in ALL pregnancies…" This was only one of numerous brand
names that DES (diethystilbestrol) was sold under.
DES did not work. In fact, the unfortunate use of this drug has
resulted in severe risks and consequences to the health of many
of the women who took the drug, as well, the daughters and sons
whom they bore.
Women who were pregnant, and daughters and sons who were born during
these years need to understand the risks that they may face because
of this exposure before birth. Special health care may be required
for some individuals to monitor for possible risks that include
cancer, and infertility, as well as other conditions.
Resources and support groups are available to help those who were
exposed to DES. It is important for everyone born during these years
to find out whether their mother was given these drugs during pregnancy.
Often this is difficult to find out because of the number of years
that have passed; however it is possible to get these records, if
you understand how to do it and where to look.
I
have heard that some women who were pregnant between 1938 and 1971
were given a drug to prevent miscarriages that is now known to cause
cancers. How do I know if I was exposed to the drug?
Many people do not know that they were exposed to DES. Mothers
may not have known they were taking DES or remember the kinds of
medication they were given when they were pregnant. Some prescription
vitamins included DES.
WHAT TO DO
Women
Who Might Have Taken DES
If you remember taking any medicine during pregnancy, try to get
your medical records.
Daughters and Sons
· Ask your mother (or other relatives who might know your mother's
pregnancy history):
· Did you (my mother) take any medications during pregnancy?
·Did you (my mother) have problems during any pregnancy, such as
bleeding, miscarriage, premature birth, or diabetes? (If so, there
is an increased possibility that your mother was given DES).
· Find out if your mother can get her medical records to see if
she took DES. If not, perhaps you can.
What
are the names of the products I (or my mother) may have taken during
pregnancy that contained DES or DES-like compounds?
Following are some names under which DES and other Nonsteroidal
Estrogens have been sold in the United States:
Nonsteroidal Estrogens
Benzestrol, Diphosphate, Hexoestrol, Oestromon, Stilpalmitate,
Chorotrainisene, Macrocyte, Diethylstilbestrol, Hi-Bestrol, Orestol,
Stiphostrol, Comestrol, Dipropianate, Menocrin, Pabestrol D., Stilronate,
Cyren, Diethlstilbenediol, Meprane, Restrol, Stilrone, Cyren B.,
Digestil, Mestilbol, Stil-Rol, Stils, Delevinal, Domestrol, Mikarol,
Stilbal, Synestrin, DES, Estilben, Mikarol forti, Stilbestrol, Synestrol,
DesPlex, Estrobene, Milestrol, Stilbestronate, Synthoestrin, Dibestil,
Estrobene DP, Monomestrol, Stilbetin, Valestril, Diestryl, Estrosyn,
Neo-Oestrano I, Stilbinol, Willestrol, Dienestrol Fontal, Neo-Oestranol
II, Stilbestroform, Dienoestrol, Gynben, Nulabort, Stilboestrol,
Dipalmite, Gyneben, Oestrogenine, Stilboestrol DP, Diethlstilbestrol
Palestrol, Hexestrol, Oestromenin, Stilestrate
Nonsterodial Estrogen-Androgen Combinatons:
Amperone, Di-Erone, Eston, Metystil, Teserene, Tylandril, Tylosterone
Nonsteroidal Estrogen-Progesterone Combination:
Progravidium
Vaginal Cream Suppositories w/Nonsteroidal
Estrogens:
AVC Cream w/Dienestrol, Dienestrol Cream
What
kind of health problems can women and children have
if they were exposed to DES ?
WOMEN WHO TOOK DES
Women who took DES are advised to pay particular attention to their
breast care because they may have a small increase in their risk
of breast cancer. Mothers are advised to tell their DES-exposed
sons and daughters about their exposure, even if these children
have not had health problems. They need to know about DES so they
can get the health care they need.
DES
CHILDREN
DES SONS
Men exposed to DES before birth
DES sons are at increased risk for non-cancerous cysts on the back
of the testicles (on the epididymis) and for underdeveloped testicles.
DES sons should practice testicular self-examination regularly.
There has been little research on the effects of DES exposure in
DES sons, but new studies are in progress. To protect your health,
find out if you were exposed, and stay informed of new research
findings.
DES DAUGHTER
Women exposed to DES before birth
All DES daughters need regular screening exams for a rare form
of vaginal cancer (early detection saves lives). This exam is somewhat
different form the one for non-expose women (see page 17). It should
begin at puberty and continue throughout their lives.
All DES daughters need special care beginning in the first weeks
of pregnancy, even if they have already had children. You can learn
about the pregnancy care you need in this booklet. With proper care
most DES daughter can have successful pregnancies.
Breast
Cancer
It is likely that breast cancer develops as a result of complex
interactions among hormonal, genetic, and environmental factors.
The incidence of breast cancer has increased over the past several
decades, and today 1 in 8 or 9 women in the United States will develop
this cancer in her lifetime. There is general agreement that a woman's
lifetime exposure to estrogens is an important influence on her
likelihood of developing breast cancer. Early menarche and delayed
menopause are associated with an increased risk.
Testicular
Cancer
Testicular cancer is also increasing around the world, with some
countries reporting a 4-5 fold increase over the past 30 years,
though it still remains much less common than other malignancies.
Epidemiological links to early hormone exposure include the following
observations:
Undescended testes (or cryptorchidism) is a major risk factor for
developing testicular cancer. Fetal estrogen exposure is a known
cause of undescended testes (DES provides an example).
First-born males have a higher incidence of testicular cancer,
and first pregnancies have higher early estrogen levels than subsequent
pregnancies.
Prostate
cancer
There is general agreement that the incidence of prostate cancer
is also increasing even after taking into account early diagnosis
resulting from increasing use of newly-available blood tests. Approximately
40,000 men in the US die of this disease annually.
Male mice exposed to DES, estrogen, or bisphenol A develop enlargement
and inflammation of the prostate. We have known for some time that
the likelihood of prostate cancer increases with age and that many
elderly men who die of other causes also have incidental prostate
cancer which is unrelated to their deaths. But a recent human autopsy
study shows that prostate cancer may develop much earlier than previously
realized. This study found that, of 152 men who died of other unrelated
causes, all less than 50 years old, 34% had evidence of cancer in
their prostates when examined microscopically. Of those less than
40 yrs. old, 27% had prostate cancer. These remarkably high percentages,
along with the animal data, suggest that prostate cancer may be
yet another malignancy whose foundation is laid early in life, perhaps
even in utero, but which does not be come apparent until later when
hormone changes stimulate the dormant cancer to grow.
Sperm
Counts
A series of studies in Europe, the UK, and the US indicate that
there has probably been a substantial decline in human sperm counts
over the past 40 years. Problems such as age, period of abstinence
from sexual activity, and individual and geographical variability
make this challenging to investigate, but the weight of evidence
indicates a significant decline.
A
recently published autopsy study of men who died of various causes
unrelated to their reproductive tract compared results from 1991
with those obtained from a similar population of men in 1981, corrected
for age and various other medical and social factors. In this study,
the percentage of subjects with normal spermatogenesis on microscopic
exam of their testes declined from 56% to 27% over the ten-year
period. Complete spermatogenic arrest increased from 8% to 20% over
the same period.
Altered neurological development, behavior,
and learning
Studies in monkeys and rodents indicate that in utero exposure
to dioxin, PCBs, and estrogenic chemicals can alter behavior and
learning ability. Several human studies have similar findings.
Studies also showed that when expectant mothers consumed PCB-contaminated
fish before and during pregnancy, this exposed their developing
fetuses to this organochlorine during critical times of brain development.
One study of children followed for 11 years shows that those in
the highest exposure group have an IQ deficit of about 6 points.
Projected onto an entire population, this amounts to a large downward
shift in the number of people with above average intellegence. Many
more people with learning disabilities would also increase significantly.
It is a biological phenomenon with enormous social consequences.
Laboratory studies suggest that the mechanism of this adverse effect
may be through interference with thyroid hormone metabolism, though
this is not known with certainty.
Other
health effects
There are also data linking exposure to endocrine disruptors with
other medical conditions. For example, a study of primates exposed
to small amounts of dietary dioxin showed development of endometriosis.
Some laboratory animal tests show a relationship
between fetal estrogenic exposures and subsequent poor development
of immunity.
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